Optical properties of quantum dot-metal composites and their applications in detection of prostate cancer biomarkers = 양자점-금속 합성물의 광학특성 및 전립선 암 생물지표 탐지의 응용

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Due to unique optical and electrical properties, such as broad excitation region, narrow emission area, tunable optical properties, strong luminescence, and excellent photostability compared to conventional organ-ic dyes, luminescent semiconductor quantum dots (QDs) have been utilized in wide applications in biology such as biological imaging, DNA detection, multiplexing beads, and efficient donors in fluorescence (Forster) resonance energy transfer (FRET) mechanisms. Recently, the QDs- metal nanoparticle (NP) composites have offered highly promising potential applications in nanotechnology and biotechnology because of their interest-ing properties, such as fluorescence enhancement and quenching effects. Considerable theoretical and experi-mental effort is being made to understand the mechanisms of the photoluminescence (PL) enhancement and quenching phenomenon for QDs-metal composites. However, understanding on the mechanism and potential applications of the fluorescence quenching phenomenon is still very limited. Properties of the QDs-metal com-posites have been performed in a solid state. For real biological applications, the QDs-metal composites with unique optical properties should be available in a water solution, while there have been only a few research works on the composites dispersed in a water solution. Even though some research had worked on the optical properties in aqueous solution, it is still not enough to systematically understand the quenching and enhance-ment mechanisms in our own QDs-metal system. The aims of this research are to gain deep understanding of PL quenching and enhancement dynamics in QDs-metal composites, and to obtain a new protein chip detection system with high sensitivity and low limit of detection (LOD) by using QDs- metal composites. The first study in this dissertation is to investigate the fluorescence dynamics of QDs-metal compo-sites. We indicated a systematical study of optical properties, ...
Advisors
Cho, Yong-Hoonresearcher조용훈
Description
한국과학기술원 : 물리학과,
Publisher
한국과학기술원
Issue Date
2012
Identifier
511399/325007  / 020095392
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 물리학과, 2012.8, [ viii, 76 p. ]

Keywords

Quantum dots; gold nanoparticles; PL quenching; SPR; 양자점; 금 나노입자; PL 검소; 표면 플라스몬 공명; 표면 플라스몬 결합 방출; SPCE

URI
http://hdl.handle.net/10203/182346
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=511399&flag=dissertation
Appears in Collection
PH-Theses_Ph.D.(박사논문)
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