Protective effects of bio-active ceramic water on alcohol-induced hepatic injury in pigs

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Among many detrimental injuries, alcohol is implicated in hepatitis, fatty liver, hepatic fibrosis, and cirrhosis. The purpose of this study Was to evaluate the protective effect of bio-active ceramic water on alcohol-induced hepatic injury in pigs. Twelve male Landrace pigs were divided into 3 groups. Groups 1, 2, and 3 were fed with bio-active ceramic water + normal liquid diet, bio-active ceramic water + liquid diet containing 15% ethanol, and tap water + liquid diet containing 15% ethanol for 12 weeks, respectively. For serological, histopathological, and immunohistochemical analysis, all pigs were sacrificed at week 12. In group 3, serum ALT and AST levels increased, and mild fatty change and moderate necrosis were detected in the liver. Collagen fibers, myofibroblasts, and CYP2E1 Were also increased or activated in group 3. In group 2, there were mild hepatic injuries compared to group 3. However, injuries and activations were not observed in the liver in group 1. We suggest that the bio-active ceramic water used in the present study had protective capability against ethanol-induced hepatic injury and that having no toxic effect on the pig liver. The bio-active ceramic water might be useful as a therapeutic drinking water in patients suffering from alcoholic liver diseases.
Publisher
Japan Soc Vet Sci
Issue Date
2005-04
Language
English
Article Type
Article
Keywords

ETHANOL-OXIDIZING SYSTEM; LIVER-DISEASE; RAT-LIVER; LIPID-PEROXIDATION; FIBROSIS; BABOON; CYTOCHROME-P-450; FIBROGENESIS; PATHOGENESIS; METABOLISM

Citation

JOURNAL OF VETERINARY MEDICAL SCIENCE, v.67, no.4, pp.403 - 409

ISSN
0916-7250
DOI
10.1292/jvms.67.403
URI
http://hdl.handle.net/10203/17560
Appears in Collection
MSE-Journal Papers(저널논문)
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