DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state

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Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan. (C) 2013 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2013-07
Language
English
Article Type
Article
Keywords

LIFE-SPAN; LONGEVITY; GENE; IDENTIFICATION; METABOLISM; DIAPAUSE; HOMOLOGS; MUTANT; PTEN; LONG

Citation

GENE, v.524, no.2, pp.373 - 376

ISSN
0378-1119
DOI
10.1016/j.gene.2013.04.032
URI
http://hdl.handle.net/10203/175034
Appears in Collection
BS-Journal Papers(저널논문)
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