Phytochrome-interacting factors have both shared and distinct biological roles

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Phytochromes are plant photoreceptors that perceive red and far-red light. Upon the perception of light in Arabidopsis, light-activated phytochromes enter the nucleus and act on a set of interacting proteins, modulating their activities and thereby altering the expression levels of similar to 10% of the organism's entire gene complement. Phytochromeinteracting factors (PIFs) belonging to Arabidopsis basic helix-loop-helix (bHLH) subgroup 15 are key interacting proteins that play negative roles in light responses. Their activities are post-translationally countered by light-activated phytochromes, which promote the degradation of PIFs and directly or indirectly inhibit their binding to DNA. The PIFs share a high degree of similarity, but examinations of pif single and multiple mutants have indicated that they have shared and distinct functions in various developmental and physiological processes. These are believed to stem from differences in both intrinsic protein properties and their gene expression patterns. In an effort to clarify the basis of these shared and distinct functions, we compared recently published genome-wide ChIP data, developmental gene expression maps, and responses to various stimuli for the various PIFs. Based on our observations, we propose that the biological roles of PIFs stem from their shared and distinct DNA binding targets and specific gene expression patterns.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2013-05
Language
English
Article Type
Review
Keywords

SHADE-AVOIDANCE-RESPONSE; LOOP-HELIX PROTEIN; ARABIDOPSIS-THALIANA DEVELOPMENT; TRANSCRIPTION FACTOR SPATULA; SEED-GERMINATION; SIGNAL-TRANSDUCTION; MEDIATED DEGRADATION; MOLECULAR FRAMEWORK; NEGATIVE REGULATOR; PLANT ARCHITECTURE

Citation

MOLECULES AND CELLS, v.35, no.5, pp.371 - 380

ISSN
1016-8478
DOI
10.1007/s10059-013-0135-5
URI
http://hdl.handle.net/10203/174778
Appears in Collection
BS-Journal Papers(저널논문)
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