In this study, aerodynamic design optimization of airfoil was performed to minimize drag of baseline airfoil at transonic flow by using e-Science based design framework. Prior to the design optimization, parameter sensitivity studies were performed to determine the step-size and the sensitivity of the objective function. In this research, the weight of a Hicks-Henne bump function served as a design variable. Aerodynamic analysis was carried out by EDISON_CFD Solver. An aerodynamic design optimization framework of airfoil selected a drag-minimized optimal configuration by using the gradient-based optimization algorithm. Design results showed that the drag and lift performances of an optimized airfoil have been improved by 95% and 7% respectively. In addition, the performance of an optimized airfoil was validated by performing the off-design study in different design flow conditions. Through this study, A aerodynamic design optimization framework of airfoil can be utilized as an educational & research aerodynamic design optimization resource.