Analysis of the Genome-Scale Metabolic Model of Pichia pastoris

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Here we present the analysis of the genome-scale metabolic model of the yeast Pichia pastoris, an attractive host for heterologous protein production and capable of producing proteins of therapeutic value. Using the genome-scale metabolic model, characteristics and capacity towards the production of two proteins, human serum albumin (HSA) and human superoxide dismutase (hSOD), were analyzed and metabolic engineering targets were suggested to improve their production. Using genome-scale metabolic model, potential phenotypes can be screen in a high-throughput manner, accelerating the development of strategies for engineering improved strains.
Publisher
한국화학공학회
Issue Date
2010-10-20
Language
Korean
Citation

Annual Fall Meeting of KIChE 2010

URI
http://hdl.handle.net/10203/172061
Appears in Collection
CBE-Conference Papers(학술회의논문)
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