This paper presents the synergetic use of the Axiomatic Design principles and FMECA (Failure mode, effects, and criticality analysis) for the reliability-critical system design. The hierarchical structures of the Axiomatic Design and The FMECA are reviewed and the possible synergetic use in the FR-DP assignment. The Proposed methodology is validated in the case study of the Mobile Harbor docking system design. Keywords Conceptual Design, Reliability, Axiomatic Design, FMECA, Mobile Harbor