Bioelectrocatalyzed signal amplification for affinity interactions at chemically modified electrodes

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A comparative study was performed to evaluate the signal amplification strategies in electrochemical affinity sensing, which included the direct electron transfer and diffusible-group mediated electron transfer between label enzymes that were specifically bound to target proteins and chemically modified electrode surfaces. As a platform surface for affinity recognition reactions, a double functionalized poly(amidoamine) dendrimer monolayer that was modified with ferrocene and biotin groups was constructed on a gold surface. With the chemically modified electrode, a model affinity sensing with avidin was investigated. The advantages of adopting the diffusible-group mediated signaling strategy were demonstrated in terms of signal sensitivity and stability.
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Issue Date
2004-03
Language
English
Article Type
Article
Keywords

ORGANIZED ASSEMBLIES; DENDRIMER MONOLAYER; CONSTRUCTION; IMMUNOASSAYS; BIOMOLECULES; PROTEIN; AVIDIN; ASSAY; GOLD

Citation

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.9, no.2, pp.107 - 111

ISSN
1226-8372
DOI
10.1007/BF02932992
URI
http://hdl.handle.net/10203/14397
Appears in Collection
BS-Journal Papers(저널논문)
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