Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation

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Poly(L-lactic acid) and its copolymers with D-lactic and glycolic acid were used to fabricate various porous biodegradable scaffolds suitable for tissue engineering and drug delivery based on a thermally induced phase separation (TIPS) technique. A variety of parameters involved in TIPS process, such as types of polymers, polymer concentration, solvent/nonsolvent ratio, and quenching temperature, were examined in detail to produce a wide array of micro- and macroporous structures. A mixture of dioxane and water was used for a binary composition of solvent and nonsolvent, respectively In particular, the coarsening effect of pore enlargement affected by controlling the quenching temperature was used for the generation of a macroporous open cellular structure with pore diameters above 100 mu m. The use of amorphous polymers with a slow cooling rate resulted in a macroporous open cellular structure, whereas that of semicrystalline polymers with a fast cooling rate generated a microporous closed cellular structure. The fabricated porous devices loaded with recombinant human growth hormone (rhGH) were tested for the controlled delivery of rhGH, as a potential additional means to cell delivery. (C) 1999 John Wiley & Sons, Inc.
Publisher
JOHN WILEY & SONS INC
Issue Date
1999
Language
English
Article Type
Article
Keywords

MICROPOROUS MEMBRANE FORMATION; POLY(L-LACTIC ACID) FOAMS; SPINODAL DECOMPOSITION; TRANSPLANTATION; MIXTURES; SPONGES

Citation

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, v.47, no.1, pp.8 - 17

ISSN
0021-9304
DOI
10.1002/(SICI)1097-4636(199910)47:1<8::AID-JBM2>3.0.CO;2-L
URI
http://hdl.handle.net/10203/13204
Appears in Collection
MS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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