DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Jaeseung | ko |
dc.contributor.author | Shi, Wei-Xing | ko |
dc.contributor.author | Hoffman, Ralph | ko |
dc.contributor.author | Oh, Jihoon | ko |
dc.contributor.author | Gore, John C. | ko |
dc.contributor.author | Bunney, Benjamin S. | ko |
dc.contributor.author | Peterson, Bradley S. | ko |
dc.date.accessioned | 2013-03-13T05:03:03Z | - |
dc.date.available | 2013-03-13T05:03:03Z | - |
dc.date.created | 2012-12-24 | - |
dc.date.created | 2012-12-24 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF NEUROSCIENCE, v.36, no.9, pp.3214 - 3223 | - |
dc.identifier.issn | 0953-816X | - |
dc.identifier.uri | http://hdl.handle.net/10203/104521 | - |
dc.description.abstract | Nigral dopamine (DA) neurons in vivo exhibit complex firing patterns consisting of tonic single-spikes and phasic bursts that encode information for certain types of reward-related learning and behavior. Non-linear dynamical analysis has previously demonstrated the presence of a non-linear deterministic structure in complex firing patterns of DA neurons, yet the origin of this non-linear determinism remains unknown. In this study, we hypothesized that bursting activity is the primary source of non-linear determinism in the firing patterns of DA neurons. To test this hypothesis, we investigated the dimension complexity of inter-spike interval data recorded in vivo from bursting and non-bursting DA neurons in the chloral hydrate-anesthetized rat substantia nigra. We found that bursting DA neurons exhibited non-linear determinism in their firing patterns, whereas non-bursting DA neurons showed truly stochastic firing patterns. Determinism was also detected in the isolated burst and inter-burst interval data extracted from firing patterns of bursting neurons. Moreover, less bursting DA neurons in halothane-anesthetized rats exhibited higher dimensional spiking dynamics than do more bursting DA neurons in chloral hydrate-anesthetized rats. These results strongly indicate that bursting activity is the main source of low-dimensional, non-linear determinism in the firing patterns of DA neurons. This finding furthermore suggests that bursts are the likely carriers of meaningful information in the firing activities of DA neurons. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | METHYL-D-ASPARTATE | - |
dc.subject | SEQUENCE-DEPENDENT STRUCTURE | - |
dc.subject | IN-VIVO | - |
dc.subject | EXTRACELLULAR DOPAMINE | - |
dc.subject | INTERSPIKE INTERVALS | - |
dc.subject | GENERAL-ANESTHETICS | - |
dc.subject | AFFERENT MODULATION | - |
dc.subject | NEURAL INFORMATION | - |
dc.subject | STRANGE ATTRACTORS | - |
dc.subject | GLYCINE RECEPTORS | - |
dc.title | Bursting as a source of non-linear determinism in the firing patterns of nigral dopamine neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000310683800008 | - |
dc.identifier.scopusid | 2-s2.0-84868590902 | - |
dc.type.rims | ART | - |
dc.citation.volume | 36 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 3214 | - |
dc.citation.endingpage | 3223 | - |
dc.citation.publicationname | EUROPEAN JOURNAL OF NEUROSCIENCE | - |
dc.identifier.doi | 10.1111/j.1460-9568.2012.08238.x | - |
dc.contributor.localauthor | Jeong, Jaeseung | - |
dc.contributor.nonIdAuthor | Shi, Wei-Xing | - |
dc.contributor.nonIdAuthor | Hoffman, Ralph | - |
dc.contributor.nonIdAuthor | Oh, Jihoon | - |
dc.contributor.nonIdAuthor | Gore, John C. | - |
dc.contributor.nonIdAuthor | Bunney, Benjamin S. | - |
dc.contributor.nonIdAuthor | Peterson, Bradley S. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | burst | - |
dc.subject.keywordAuthor | dopamine | - |
dc.subject.keywordAuthor | non-linear determinism | - |
dc.subject.keywordAuthor | rat | - |
dc.subject.keywordAuthor | spike train | - |
dc.subject.keywordAuthor | substantia nigra | - |
dc.subject.keywordPlus | METHYL-D-ASPARTATE | - |
dc.subject.keywordPlus | SEQUENCE-DEPENDENT STRUCTURE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | EXTRACELLULAR DOPAMINE | - |
dc.subject.keywordPlus | INTERSPIKE INTERVALS | - |
dc.subject.keywordPlus | GENERAL-ANESTHETICS | - |
dc.subject.keywordPlus | AFFERENT MODULATION | - |
dc.subject.keywordPlus | NEURAL INFORMATION | - |
dc.subject.keywordPlus | STRANGE ATTRACTORS | - |
dc.subject.keywordPlus | GLYCINE RECEPTORS | - |
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