DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Chan-Woo | ko |
dc.contributor.author | Yang, Hee-Man | ko |
dc.contributor.author | Lee, Hyun-Jin | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2013-03-12T22:14:07Z | - |
dc.date.available | 2013-03-12T22:14:07Z | - |
dc.date.created | 2013-02-22 | - |
dc.date.created | 2013-02-22 | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | SOFT MATTER, v.9, no.6, pp.1781 - 1788 | - |
dc.identifier.issn | 1744-683X | - |
dc.identifier.uri | http://hdl.handle.net/10203/103689 | - |
dc.description.abstract | A new synthesis approach for the preparation of pH-responsive nanogels via core hydrolysis of cross-linked polymer micelles is proposed. The core-shell nanogels of poly(ethylene glycol)-poly(aspartic acid) exhibited a pH-responsive swelling behavior attributed to the ionization of aspartic acids, and the swelling of the nanogels depended on the cross-linking density. Small-angle neutron scattering (SANS) data were used to investigate the structure and swelling behavior of the nanogels via fitting analysis based on a new model equation that describes two distinguishable scattering intensities that arise from the particle structure and the fluctuation of polymer networks. We estimated that the nanogel core can absorb a volume of water molecules up to 30 times the volume of the polymer itself. The hydrophilic nanogels were able to entrap a protein drug, rh-insulin, and the drug release was retarded under acidic conditions due to deswelling of the nanogels. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | ANGLE NEUTRON-SCATTERING | - |
dc.subject | DRUG-DELIVERY SYSTEMS | - |
dc.subject | STRUCTURAL-CHANGES | - |
dc.subject | NANOPARTICLES | - |
dc.subject | POLYMERIZATION | - |
dc.subject | PARTICLES | - |
dc.subject | COLLOIDS | - |
dc.subject | CRYSTAL | - |
dc.subject | SIZE | - |
dc.subject | GELS | - |
dc.title | Core-shell nanogel of PEG-poly(aspartic acid) and its pH-responsive release of rh-insulin | - |
dc.type | Article | - |
dc.identifier.wosid | 000313594200007 | - |
dc.identifier.scopusid | 2-s2.0-84872542601 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1781 | - |
dc.citation.endingpage | 1788 | - |
dc.citation.publicationname | SOFT MATTER | - |
dc.identifier.doi | 10.1039/c2sm26865e | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.nonIdAuthor | Lee, Hyun-Jin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANGLE NEUTRON-SCATTERING | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEMS | - |
dc.subject.keywordPlus | STRUCTURAL-CHANGES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMERIZATION | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | COLLOIDS | - |
dc.subject.keywordPlus | CRYSTAL | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | GELS | - |
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