Radiation sensors are essential to detect illicit radiological materials, nuclear waste management, radiochemistry, nuclear physics, and medical research. Detectors should be capable of uncovering various radiation sources with a good energy resolution and being adaptable to different platforms such as hand-held, desktop, and benchtop, which can be easily implemented for security check in harbors and airports. Many of the devices and systems presently in use are bulky and expensive. Herein, we present a new detection method and architecture based on metal oxide semiconductor field effect transistor. Some liquids react to radiation, leading to a change in properties such as dielectric constant. Inspired by such radiation-responsivity, we have constructed a transistor with a radiation-responsive liquid as a gate dielectric. Current-voltage characteristics of the device change upon gamma-ray irradiation. Different types of liquids that specifically interact with target radiations can be used in an array of transistors serving as a radiation nose in the future. Such a radiation nose can be adaptable to different platforms and for implementation as a dosimeter for radiotherapy patients, nuclear plant health and safety inspection, space travel, environmental monitoring, and sensors for security. Published by Elsevier B.V.