The inorganic DMSO/POCl3 reaction with BODIPY: wide product formation and implications for biological ROS sensing and neurodegenerative disease research

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We report a refined and expanded synthetic study of 4,4-difluoro-1,3,5,7-tetramethyl-8-(aryl)-4-bora-3a,4a-diaza-s-indacene under treatment with POCl3/DMSO. The 2-chloro-6-methylsulfide derivative (Kim TI, Park S, Choi Y and Kim Y. Chem. Asian J. 2011; 6: 1358-61.) was one of five co-eluants, including 2,6-disulfido and -dichloro species, and mono-substituted counterparts. The 8-meso tail group modifies product distribution. The different sulfur-containing products undergo different "off-on" responses with NaOCl (10 equiv.). Compounds 4b and 2b exhibit low toxicity and were found to enter juxtanuclear regions in neuroblastoma.
Publisher
WORLD SCI PUBL CO INC
Issue Date
2012-11
Language
English
Article Type
Article
Keywords

OPTICAL-PROPERTIES; DYES; FLUORESCENCE; SYSTEMS; DIPYRROMETHANES; DERIVATIVES; DIPYRRINS

Citation

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, v.16, no.11, pp.1201 - 1208

ISSN
1088-4246
DOI
10.1142/S1088424612501180
URI
http://hdl.handle.net/10203/102552
Appears in Collection
CH-Journal Papers(저널논문)
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