Removal of potassium chloride by nanofiltration from ion-exchanged solution containing potassium clavulanate

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In this study, nanofiltration with NF200 membrane was employed to remove KCl from ion-exchanged solutions containing potassium clavulanate. The pore radius of NF200 membrane was estimated to be around 0.39 nm. The effects of operating pressure on separation performance were investigated in a range of 100-400 psig. The influences of cross-flow velocity (0.14-0.70 cm/s), temperature (4-25 A degrees C), and feed composition were also investigated. In all experiments, clavulanate rejection showed high levels from 0.91 to 0.99, while chloride rejection ranged from 0.06 to 0.54. In a case at an operating pressure of 50 psig and 25 A degrees C, as much as 94% of clavulanate was retained while 94% of chloride was removed, indicating that NF200 membrane was a suitable choice for selectively removing KCl. NF200 membrane also showed a stable performance in the operational stability test with an ion-exchanged solution obtained by treating actual fermentation broth.
Publisher
SPRINGER
Issue Date
2010-01
Language
English
Article Type
Article
Keywords

NATURAL ORGANIC-MATTER; OPERATING-CONDITIONS; MEMBRANES; SEPARATION; WATER; ACID; PERFORMANCE; REJECTION; RETENTION; TRANSPORT

Citation

BIOPROCESS AND BIOSYSTEMS ENGINEERING, v.33, no.1, pp.149 - 158

ISSN
1615-7591
DOI
10.1007/s00449-009-0360-7
URI
http://hdl.handle.net/10203/101158
Appears in Collection
CBE-Journal Papers(저널논문)
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