Due to high spectral-efficiency of multiple-input multiple-output (MIMO) transmission techniques, IEEE 802.11n WLAN system adopted a single-user MIMO (SU-MIMO) scheme in which multiple symbol streams are transmitted from a single station (STA) to enhance the system performance. On the other hand, recently, adoption of a multi-user MIMO (MU-MIMO) scheme for multi-packet reception (MPR) in uplink WLAN has also attracted attention. The SU-MIMO scheme achieves a MIMO multiplexing gain at physical (PHY) layer while the MU-MIMO scheme achieves a MIMO multiplexing gain at medium access control (MAC) layer. Thus, there is a fundamental question which scheme is a better solution for uplink WLANs and, in this paper, we analyze and compare these two schemes with random STA distribution scenarios. Moreover, with the adaptation of MAC layer parameters, we also analyze and compare the maximum throughput performance of both the SU- and MU-MIMO schemes in uplinkWLANs and we find a proper decision criterion to select the MIMO mode in uplink WLANs.