Researcher Page

Helfman, David M. (데이비드 헬프만)
교수, Department of Biological Sciences(생명과학과)
Research Area
Cell Signaling
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    NO Title, Author(s) (Publication Title, Volume Issue, Page, Issue Date)
    Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells

    Shin, Hyerim; Kim, Dayoung; Helfman, David M.researcher, ONCOTARGET, v.8, no.56, pp.95192 - 95205, 2017-11

    Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling

    Jeong, Sukyeong; Lim, SunYoung; Schevzov, Galina; et al, ONCOTARGET, v.8, no.20, pp.33544 - 33559, 2017-05

    Integrin beta 1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer

    Choi, Cheolwon; Kwon, Junyeob; Lim, Sunyoung; et al, ONCOTARGET, v.7, no.39, pp.63466 - 63487, 2016-09

    Loss of MLCK leads to dleisruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling

    Kim, Dayoung; Helfman, David M.researcher, ONCOGENE, v.35, no.34, pp.4495 - 4508, 2016-08

    The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2

    Choi, Cheolwon; Helfman, David Mresearcher, ONCOGENE, v.33, no.28, pp.3668 - 3676, 2014-07

    Modeling of Menkes disease via human induced pluripotent stem cells

    Suh, Ji Hoon; Kim, Dong Kyu; Kim, Hyemin; et al, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.444, no.3, pp.311 - 318, 2014-01

    From skeletal muscle to cancer: Insights learned elucidating the function of tropomyosin

    Choi, Cheolwon; Kim, Dayoung; Kim, Sabina; et al, JOURNAL OF STRUCTURAL BIOLOGY, v.177, no.1, pp.63 - 69, 2012-01

    Niclosamide: An Established Antihelminthic Drug as a Potential Therapy Against S100A4-Mediated Metastatic Colon Tumors

    Helfman, David Mresearcher, JOURNAL OF THE NATIONAL CANCER INSTITUTE, v.103, no.13, pp.991 - 992, 2011-07

    Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

    Lu, Xiaoqing; Kazmierczak, Katarzyna; Jiang, Xiaoyu; et al, FEBS JOURNAL, v.278, no.11, pp.1922 - 1931, 2011-06

    HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway

    Jiang, Xiaoyu; Lu, Xiaoqing; McNamara, George; et al, BLOOD, v.116, no.24, pp.5217 - 5227, 2010-12

    Non-Muscle Myosin IIB Helps Mediate TNF Cell Death Signaling Independent of Actomyosin Contractility (AMC)

    Flynn, Patrick G.; Helfman, David Mresearcher, JOURNAL OF CELLULAR BIOCHEMISTRY, v.110, no.6, pp.1365 - 1375, 2010-08

    RSK1 drives p27(Kip1) phosphorylation at T198 to promote RhoA inhibition and increase cell motility

    Larreaa, Michelle D.; Hong, Feng; Wander, Seth A.; et al, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.106, no.23, pp.9268 - 9273, 2009-06

    Tropomyosin as a Regulator of Cancer Cell Transformation

    Helfman, David Mresearcher; Flynn, Patrick; Khan, Protiti; et al, TROPOMYOSIN BOOK SERIES: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, v.644, pp.124 - 131, 2008

    HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration

    Lu, Xiaoqing; Chen, Jun; Malumbres, Raquel; et al, BLOOD, v.110, no.13, pp.4268 - 4277, 2007-12

    Myosin light chain kinase plays a role in the regulation of epithelial cell survival

    Connell, Laureen E.; Helfman, David Mresearcher, JOURNAL OF CELL SCIENCE, v.119, no.11, pp.2269 - 2281, 2006-06

    Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras

    Helfman, David Mresearcher; Pawlak, Geraldine, JOURNAL OF CELLULAR BIOCHEMISTRY, v.95, no.5, pp.1069 - 1080, 2005-08

    The metastasis associated protein S100A4: role in tumour progression and metastasis

    Helfman, David Mresearcher; Kim, EJ; Lukanidin, E; et al, BRITISH JOURNAL OF CANCER, v.92, no.11, pp.1955 - 1958, 2005-06

    A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells

    Bakin, Andrei V.; Safina, Alfiya; Rinehart, Cammie; et al, MOLECULAR BIOLOGY OF THE CELL, v.15, no.10, pp.4682 - 4694, 2004-10

    Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation

    Dhawan, Jyotsna; Helfman, David Mresearcher, JOURNAL OF CELL SCIENCE, v.117, no.17, pp.3735 - 3748, 2004-08

    Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder

    Pawlak, Geraldine; McGarvey, Terence W.; Nguyen, Trang B.; et al, INTERNATIONAL JOURNAL OF CANCER, v.110, no.3, pp.368 - 373, 2004-06

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