Effects of periodic stimulation on an overly activated neuronal circuit

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Motivated by therapeutic deep brain stimulation, we carried out a model study on the effects of periodic stimulation on an overly activated neuronal circuit. Our neuronal circuit, modeled as a small-world network of noisy Hodgkin-Huxley neurons, is controlled to undergo the mechanism of coherence resonance to exhibit spontaneous synchronization of neuronal firing. This state of energy burst is then directly modulated by a chain of electric pulses. Our study shows that (i) the stimulation blocks the synchronization by generating traveling waves, (ii) only the pulse with proper frequency can block the synchronization, and (iii) the effects of stimulation are completely reversible. It is also found that the stimulation is effective only when the network maintains fairly good structural regularity.
Publisher
AMER PHYSICAL SOC
Issue Date
2011-08
Language
English
Article Type
Article
Keywords

SMALL-WORLD NETWORKS; MONKEY PREFRONTAL CORTEX; COHERENCE RESONANCE; OSCILLATIONS; SEIZURES; SLICES

Citation

PHYSICAL REVIEW E, v.84, no.2

ISSN
1539-3755
URI
http://hdl.handle.net/10203/99632
Appears in Collection
PH-Journal Papers(저널논문)
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