Cerebral Glucose Metabolism of Parkinsons Disease Patients with Mild Cognitive Impairment

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Background: Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. Methods: This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 8). Using [18F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. Results: In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo-occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. Conclusions: The distribution of hypo-metabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia. Copyright (C) 2010 S. Karger AG, Basel
Publisher
KARGER
Issue Date
2010
Language
English
Article Type
Article
Keywords

ALZHEIMERS-DISEASE; BASAL FOREBRAIN; DEMENTIA; DYSFUNCTION; MEMORY; ROTATION; CORTEX

Citation

EUROPEAN NEUROLOGY, v.64, no.2, pp.65 - 73

ISSN
0014-3022
DOI
10.1159/000315036
URI
http://hdl.handle.net/10203/99613
Appears in Collection
BiS-Journal Papers(저널논문)
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