A New Entry of Copper-Catalyzed Four-Component Reaction: Facile Access to alpha-Aryl beta-Hydroxy Imidates

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alpha-Aryl beta-hydroxy imidates are efficiently obtained by the four-component reaction of ethyl glyoxylates, aryl acetylenes, sulfonyl azides, and alcohols using a copper catalyst. The developed procedure Is characterized by high selectivity, mild reaction conditions, a wide substrate scope, and an excellent functional group tolerance. Facile transformations of the obtained sulfonylimidate moiety to other carbonyl groups such as sulfonamides or esters were also demonstrated.
Publisher
AMER CHEMICAL SOC
Issue Date
2009-03
Language
English
Article Type
Article
Keywords

ONE-POT SYNTHESIS; SULFONYL AZIDES; AMIDE SYNTHESIS; AMIDINES; WATER; NUCLEOPHILES; ALKYNE

Citation

ORGANIC LETTERS, v.11, no.5, pp.1155 - 1158

ISSN
1523-7060
DOI
10.1021/ol900023t
URI
http://hdl.handle.net/10203/98842
Appears in Collection
CH-Journal Papers(저널논문)
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