Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimers disease models

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dc.contributor.authorLee, Soon-Taeko
dc.contributor.authorChu, Konko
dc.contributor.authorPark, Jung-Eunko
dc.contributor.authorJung, Keun-Hwako
dc.contributor.authorJeon, Daejongko
dc.contributor.authorLim, Ji-Younko
dc.contributor.authorLee, Sang Kunko
dc.contributor.authorKim, Manhoko
dc.contributor.authorRoh, Jae-Kyuko
dc.date.accessioned2013-03-11T06:55:48Z-
dc.date.available2013-03-11T06:55:48Z-
dc.date.created2012-03-08-
dc.date.created2012-03-08-
dc.date.issued2012-01-
dc.identifier.citationJOURNAL OF NEUROCHEMISTRY, v.120, no.1, pp.115 - 124-
dc.identifier.issn0022-3042-
dc.identifier.urihttp://hdl.handle.net/10203/98589-
dc.description.abstractNeurovascular degeneration contributes to the pathogenesis of Alzheimers disease (AD). Because erythropoietin (EPO) promotes endothelial regeneration, we investigated the therapeutic effects of EPO in animal models of AD. In aged Tg2576 mice, EPO receptors (EPORs) were expressed in the cortex and hippocampus. Tg2576 mice were treated with daily injection of EPO (5000 IU/kg/day) for 5 days. At 14 days, EPO improved contextual memory as measured by fear-conditioning test. EPO enhanced endothelial proliferation and the level of synaptophysin expression in the brain. EPO also increased capillary density, and decreased the level of the receptor for advanced glycation endproducts (RAGE) in the brain, while decreasing in the amount of amyloid plaque and amyloid-beta (A beta). In cultured human endothelial cells, EPO enhanced angiogenesis and suppressed the expression of the RAGE. These results show that EPO improves memory and ameliorates endothelial degeneration induced by A beta in AD models. This pre-clinical evidence suggests that EPO may be useful for the treatment of AD.-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.subjectRECOMBINANT-HUMAN-ERYTHROPOIETIN-
dc.subjectBLOOD-BRAIN-BARRIER-
dc.subjectAMYOTROPHIC-LATERAL-SCLEROSIS-
dc.subjectCIRCULATING ANGIOGENIC CELLS-
dc.subjectACTIVATED PROTEIN-KINASE-
dc.subjectLONG-TERM POTENTIATION-
dc.subjectMOUSE MODEL-
dc.subjectRECEPTOR EXPRESSION-
dc.subjectSTATUS-EPILEPTICUS-
dc.subjectCEREBRAL-ISCHEMIA-
dc.titleErythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimers disease models-
dc.typeArticle-
dc.identifier.wosid000298060500012-
dc.identifier.scopusid2-s2.0-83855165674-
dc.type.rimsART-
dc.citation.volume120-
dc.citation.issue1-
dc.citation.beginningpage115-
dc.citation.endingpage124-
dc.citation.publicationnameJOURNAL OF NEUROCHEMISTRY-
dc.identifier.doi10.1111/j.1471-4159.2011.07534.x-
dc.contributor.localauthorJeon, Daejong-
dc.contributor.nonIdAuthorLee, Soon-Tae-
dc.contributor.nonIdAuthorChu, Kon-
dc.contributor.nonIdAuthorPark, Jung-Eun-
dc.contributor.nonIdAuthorJung, Keun-Hwa-
dc.contributor.nonIdAuthorLim, Ji-Youn-
dc.contributor.nonIdAuthorLee, Sang Kun-
dc.contributor.nonIdAuthorKim, Manho-
dc.contributor.nonIdAuthorRoh, Jae-Kyu-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthoramyloid-beta-
dc.subject.keywordAuthorangiogenesis-
dc.subject.keywordAuthorerythropoietin-
dc.subject.keywordAuthorreceptor for advanced glycation endproducts-
dc.subject.keywordAuthorTg2576-
dc.subject.keywordPlusRECOMBINANT-HUMAN-ERYTHROPOIETIN-
dc.subject.keywordPlusBLOOD-BRAIN-BARRIER-
dc.subject.keywordPlusAMYOTROPHIC-LATERAL-SCLEROSIS-
dc.subject.keywordPlusCIRCULATING ANGIOGENIC CELLS-
dc.subject.keywordPlusACTIVATED PROTEIN-KINASE-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordPlusRECEPTOR EXPRESSION-
dc.subject.keywordPlusSTATUS-EPILEPTICUS-
dc.subject.keywordPlusCEREBRAL-ISCHEMIA-
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