DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hee-Eun | ko |
dc.contributor.author | Ahn, Hee-Chul | ko |
dc.contributor.author | Lee, Yeon-Mi | ko |
dc.contributor.author | Lee, Eun-Hae | ko |
dc.contributor.author | Seo, Yeo-Jin | ko |
dc.contributor.author | Kim, Yang-Gyun | ko |
dc.contributor.author | Kim, Kyeong Kyu | ko |
dc.contributor.author | Choi, Byong-Seok | ko |
dc.contributor.author | Lee, Joon-Hwa | ko |
dc.date.accessioned | 2013-03-11T06:45:18Z | - |
dc.date.available | 2013-03-11T06:45:18Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | FEBS LETTERS, v.585, no.5, pp.772 - 778 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98552 | - |
dc.description.abstract | The human DNA-dependent activator of IFN-regulatory factor (DAI) protein, which activates the innate immune response in response to DNA, contains two tandem Z-DNA binding domains (Z alpha and Z beta) at the NH(2) terminus. The hZ beta(DAI) structure is similar to other Z-DNA binding proteins, although it demonstrates an unusual Z-DNA recognition. We performed NMR experiments on complexes of hZ beta(DAI) with DNA duplex, d(CGCGCG)(2), at a variety of protein-to-DNA molar ratios. The results suggest that hZ beta(DAI) binds to Z-DNA via an active-di B-Z transition mechanism, where two hZ beta(DAI) proteins bind to B-DNA to form the hZ beta(DAI)-B-DNA complex; the B-DNA is subsequently converted to left-handed Z-DNA. This novel mechanism of DNA binding and B-Z conversion is distinct from Z-DNA binding of the human ADAR1 protein. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | Z-ALPHA DOMAIN | - |
dc.subject | HANDED Z-DNA | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | PROTON-EXCHANGE | - |
dc.subject | HUMAN ADAR1 | - |
dc.subject | KINETICS | - |
dc.subject | DUPLEXES | - |
dc.subject | COMPLEX | - |
dc.subject | ZBP1 | - |
dc.subject | THERMODYNAMICS | - |
dc.title | The Z beta domain of human DAI binds to Z-DNA via a novel B-Z transition pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000287960900010 | - |
dc.identifier.scopusid | 2-s2.0-79952312157 | - |
dc.type.rims | ART | - |
dc.citation.volume | 585 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 772 | - |
dc.citation.endingpage | 778 | - |
dc.citation.publicationname | FEBS LETTERS | - |
dc.identifier.doi | 10.1016/j.febslet.2011.01.043 | - |
dc.contributor.localauthor | Choi, Byong-Seok | - |
dc.contributor.nonIdAuthor | Kim, Hee-Eun | - |
dc.contributor.nonIdAuthor | Ahn, Hee-Chul | - |
dc.contributor.nonIdAuthor | Lee, Yeon-Mi | - |
dc.contributor.nonIdAuthor | Lee, Eun-Hae | - |
dc.contributor.nonIdAuthor | Seo, Yeo-Jin | - |
dc.contributor.nonIdAuthor | Kim, Yang-Gyun | - |
dc.contributor.nonIdAuthor | Kim, Kyeong Kyu | - |
dc.contributor.nonIdAuthor | Lee, Joon-Hwa | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | NMR | - |
dc.subject.keywordAuthor | Z-DNA | - |
dc.subject.keywordAuthor | Hydrogen exchange | - |
dc.subject.keywordAuthor | Z-DNA binding protein | - |
dc.subject.keywordAuthor | B-Z transition | - |
dc.subject.keywordAuthor | DNA-protein interaction | - |
dc.subject.keywordPlus | Z-ALPHA DOMAIN | - |
dc.subject.keywordPlus | HANDED Z-DNA | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | PROTON-EXCHANGE | - |
dc.subject.keywordPlus | HUMAN ADAR1 | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordPlus | DUPLEXES | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | ZBP1 | - |
dc.subject.keywordPlus | THERMODYNAMICS | - |
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