Compartment-specific q-space analysis of diffusion-weighted data from isolated rhesus optic and sciatic nerves

Cited 4 time in webofscience Cited 0 time in scopus
  • Hit : 256
  • Download : 0
We investigated compartment-specific water diffusion properties in two widely structurally different isolated bovine nerves. Sciatic and optic nerves were immersed in saline containing Gd-DTPA(2+). Consequently, T(1) became non-monoexponential and fit well to a biexponential function. q-Space diffusion data were collected for each component. In the sciatic nerve, the slow-decaying component (T,,) was considerably more restricted and directional than the fast-decaying component (T(1f)). In the optic nerve, fractional anisotropy of both components was comparable and similar to that of the total H(2)O signal. The root mean square of the displacement distribution functions of T(1s) correlated well with the widely different axonal diameters of both nerves. Possibly, the Source of T1, is the intra-axonal compartment and that of T(1f) is associated with the inter-axonal space. The compartment specificity of the method shown makes it useful for the investigation of the contribution of each nerve compartment to diffusion tensor imaging measurements and other diffusion-based methods. (C) 2009 Elsevier Inc. All rights reserved.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2009-05
Language
English
Article Type
Article
Keywords

RAT SPINAL-CORD; WATER DIFFUSION; PERIPHERAL-NERVE; MYELIN WATER; MULTIPLE-SCLEROSIS; T-2 COMPONENTS; AXON DIAMETER; HUMAN BRAIN; IN-VIVO; NMR

Citation

MAGNETIC RESONANCE IMAGING, v.27, no.4, pp.531 - 540

ISSN
0730-725X
DOI
10.1016/j.mri.2008.08.007
URI
http://hdl.handle.net/10203/98388
Appears in Collection
EE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 4 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0