Tumor Self-Seeding by Circulating Cancer Cells

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Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call "tumor self-seeding." Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, including those with bone, lung, or brain-metastatic tropism. We find that the tumor-derived cytokines IL-6 and IL-8 act as CTC attractants whereas MMP1/collagenase-1 and the actin cytoskeleton component fascin-1 are mediators of CTC infiltration into mammary tumors. We show that self-seeding can accelerate tumor growth, angiogenesis, and stromal recruitment through seed-derived factors including the chemokine CXCL1. Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.
Publisher
CELL PRESS
Issue Date
2009-12
Language
English
Article Type
Article
Keywords

BREAST-CANCER; LUNG METASTASIS; INTERLEUKIN-6; MELANOMA; IL-6; INFLAMMATION; FASCIN; GENES; DISSEMINATION; ANGIOGENESIS

Citation

CELL, v.139, no.7, pp.1315 - 1326

ISSN
0092-8674
DOI
10.1016/j.cell.2009.11.025
URI
http://hdl.handle.net/10203/97248
Appears in Collection
BS-Journal Papers(저널논문)
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