Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation

Cited 33 time in webofscience Cited 0 time in scopus
  • Hit : 290
  • Download : 0
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanopartides that exhibited superb cellular uptake efficiency and gene silencing activity.
Publisher
AMER CHEMICAL SOC
Issue Date
2011-09
Language
English
Article Type
Article
Keywords

ATOMIC-FORCE MICROSCOPY; DOUBLE-STRANDED-RNA; DNA HYDROGEL; INTERFERENCE; DELIVERY; LONG; MOLECULE; SIZE; TOOL; AFM

Citation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.35, pp.13914 - 13917

ISSN
0002-7863
URI
http://hdl.handle.net/10203/95372
Appears in Collection
BS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 33 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0