Acetone Cyanohydrin as a Source of HCN in the Cu-Catalyzed Hydrocyanation of alpha-Aryl Diazoacetates

Cited 41 time in webofscience Cited 0 time in scopus
  • Hit : 199
  • Download : 0
A procedure for the Cu-catalyzed hydrocyanation of alpha-aryl diazoesters has been developed using acetone cyanohydrin as a source of hydrogen cyanide (HCN). It was found that the addition of trimethylsilyl cyanide (TMSCN) significantly accelerates the conversion presumably by delivering free cyanide ion in situ, thus producing various types of alpha-aryl cyanoacetates in high yields under mild conditions.
Publisher
AMER CHEMICAL SOC
Issue Date
2010-04
Language
English
Article Type
Article
Keywords

WEAKLY COORDINATING ANIONS; H INSERTION REACTIONS; DIAZO-COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; QUATERNARY STEREOCENTERS; DIAZOCARBONYL COMPOUNDS; ASYMMETRIC CATALYST; RHODIUM CARBENOIDS; COPPER; DERIVATIVES

Citation

JOURNAL OF ORGANIC CHEMISTRY, v.75, no.8, pp.2760 - 2762

ISSN
0022-3263
DOI
10.1021/jo100356d
URI
http://hdl.handle.net/10203/94073
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 41 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0