A facile synthesis of (S)-felodipine

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A short and facile synthesis of (S)-felodipine was developed starting from (R)-glycidol as the source of the chiral auxiliary. 2-Hydroxyethyl esters were found to undergo selective transesterification reactions in the presence of other esters. This selective transesterification reaction was applied to the synthesis of (S)-felodipine through selective substitution of the 2-hydroxyethyl group possessing chiral ester with sodium methoxide. (C) 2011 Elsevier Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
2011-12
Language
English
Article Type
Article
Keywords

ASYMMETRIC-SYNTHESIS; CALCIUM-ANTAGONIST; TRANSESTERIFICATION; DERIVATIVES

Citation

TETRAHEDRON, v.67, no.52, pp.10222 - 10228

ISSN
0040-4020
URI
http://hdl.handle.net/10203/94027
Appears in Collection
CH-Journal Papers(저널논문)
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