Palladium-Catalyzed Oxidative Alkynylation of Heterocycles with Terminal Alkynes under Air Conditions
Pd-Catalyzed oxidative alkynylation of azoles with terminal alkynes was developed via simultaneous activation of both heterocyclic sp(2) C-H and alkynyl sp C-H bonds. The choice of palladium catalyst source and external base resulted in being important factors for performing the reaction with high efficiency and selectivity, and air was successfully utilized as an environmental oxidant in the present alkynylation procedure.
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 2011-03
- Language
- English
- Article Type
- Article
- Keywords
H BOND ACTIVATION; ELECTRON-DEFICIENT POLYFLUOROARENES; PROTON-ABSTRACTION MECHANISM; CROSS-COUPLING REACTIONS; C-H; INTRAMOLECULAR ARYLATION; ROOM-TEMPERATURE; DIRECT AMINATION; FUNCTIONALIZATION; COMPLEXES
- Citation
ORGANIC LETTERS, v.13, no.6, pp.1474 - 1477
- ISSN
- 1523-7060
- Appears in Collection
- CH-Journal Papers(저널논문)
- Files in This Item
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