The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process

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The two Parkinson's disease (PD) genes, PTEN-induced kinase 1 (PINK1) and parkin, are linked in a common pathway which affects mitochondrial integrity and function. However, it is still not known what this pathway does in the mitochondria. Therefore, we investigated its physiological function in Drosophila. Because Drosophila PINK1 and parkin Mutants show changes in mitochondrial morphology in both indirect flight muscles and dopaminergic neurons, we here investigated whether the PINK1-Parkin pathway genetically interacts with the regulators of mitochondrial fusion and fission such as Drp1, which promotes mitochondrial fission, and Opal or Marf, which induces mitochondrial fusion. Surprisingly, Drosophila PINK1 and parkin mutant phenotypes were markedly suppressed by overexpression of Drp1 OF downregulation of Opal or Marf, indicating that the PINK1-Parkin pathway regulates mitochondrial remodeling process in the direction of promoting mitochondrial fission. Therefore, we strongly suggest that mitochondrial fusion and fission process could be a prominent therapeutic target for the treatment of PD. (C) 2008 Elsevier Inc. All rights reserved.
Publisher
Academic Press Inc Elsevier Science
Issue Date
2009-01
Language
English
Article Type
Article
Keywords

PARKINSONS-DISEASE; DROSOPHILA; MUTATIONS; PINK1; GENE; PATHOLOGY; DYNAMICS

Citation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.378, no.3, pp.518 - 523

ISSN
0006-291X
DOI
10.1016/j.bbrc.2008.11.086
URI
http://hdl.handle.net/10203/93554
Appears in Collection
BS-Journal Papers(저널논문)
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