DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jino | ko |
dc.contributor.author | Suh, William I. | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2013-03-08T15:08:51Z | - |
dc.date.available | 2013-03-08T15:08:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | IMMUNE NETWORK, v.10, no.4, pp.120 - 125 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93362 | - |
dc.description.abstract | Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional CD8 T cells often overexpress various inhibitory receptors. Programmed cell death 1 (PD-1) was the first among these inhibitory receptors that were identified to be overexpressed in functionally impaired T cells. The roles of other inhibitory receptors such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) have also been demonstrated in T-cell dysfunctions that occur in chronic HCV patients. Blocking these inhibitory receptors in vitro restores the functions of HCV-specific CD8 T cells and allows enhanced proliferation, cytolytic activity and cytokine production. Therefore, the blockade of the inhibitory receptors is considered as a novel strategy for the treatment of chronic HCV infection. | - |
dc.language | English | - |
dc.publisher | 대한면역학회 | - |
dc.title | T-Cell Dysfunction and Inhibitory Receptors in Hepatitis C Virus Infection | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 120 | - |
dc.citation.endingpage | 125 | - |
dc.citation.publicationname | IMMUNE NETWORK | - |
dc.identifier.kciid | ART001479623 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Lee, Jino | - |
dc.contributor.nonIdAuthor | Suh, William I. | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Hepatitis C virus | - |
dc.subject.keywordAuthor | CD8 T cells | - |
dc.subject.keywordAuthor | T-cell dysfunction | - |
dc.subject.keywordAuthor | PD-1 | - |
dc.subject.keywordAuthor | CTLA-4 | - |
dc.subject.keywordAuthor | Tim-3 | - |
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