DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Ho | ko |
dc.contributor.author | Kim, Chul Hoon | ko |
dc.contributor.author | Seo, Gi Ho | ko |
dc.contributor.author | Lee, Jinu | ko |
dc.contributor.author | Kim, Joo Hee | ko |
dc.contributor.author | Kim, Dong Goo | ko |
dc.contributor.author | Ahn, Young Soo | ko |
dc.date.accessioned | 2013-03-08T13:58:33Z | - |
dc.date.available | 2013-03-08T13:58:33Z | - |
dc.date.created | 2012-10-09 | - |
dc.date.created | 2012-10-09 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | KOREAN JOURNAL OF PHYSIOLOGY PHARMACOLOGY, v.12, no.5, pp.231 - 236 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93184 | - |
dc.description.abstract | Heparin is a well-known anticoagulant widely used in various clinical settings. Interestingly, recent studies have indicated that heparin also has anti-inflammatory effects on neuroinflammation-related diseases, such as Alzheimer's disease and meningitis. However, the underlying mechanism of its actions remains unclear. In the present study, we examined the anti-inflammatory mechanism of heparin in cultured cerebral endothelial cells (CECs), and found that heparin inhibited the tumor necrosis factor a (TNF alpha)-induced and nuclear factor kappa B (NF-kappa B)-dependent expression of adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which are crucial for inflammatory responses. Heparin selectively interfered with NF-kappa B DNA-binding activity in the nucleus, which is stimulated by TNF alpha. In addition, non-anticoagulant 2,3-O desulfated heparin (ODS) prevented NF-kappa B activation by TNF alpha, suggesting that the anti-inflammatory mechanism of heparin action in CECs lies in heparin's ability to inhibit the expression of cell adhesion molecules, as opposed to its anticoagulant actions. | - |
dc.language | English | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY PHARMACOLOGY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | BLOOD-BRAIN-BARRIER | - |
dc.subject | LEUKOCYTE ADHESION | - |
dc.subject | P-SELECTIN | - |
dc.subject | INFLAMMATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ACTIVATION | - |
dc.subject | TRANSPORT | - |
dc.subject | ARTHRITIS | - |
dc.subject | CYTOKINES | - |
dc.title | Heparin Attenuates the Expression of TNF alpha-induced Cerebral Endothelial Cell Adhesion Molecule | - |
dc.type | Article | - |
dc.identifier.wosid | 000261263100003 | - |
dc.identifier.scopusid | 2-s2.0-56749112529 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 231 | - |
dc.citation.endingpage | 236 | - |
dc.citation.publicationname | KOREAN JOURNAL OF PHYSIOLOGY PHARMACOLOGY | - |
dc.contributor.localauthor | Lee, Jeong Ho | - |
dc.contributor.nonIdAuthor | Kim, Chul Hoon | - |
dc.contributor.nonIdAuthor | Seo, Gi Ho | - |
dc.contributor.nonIdAuthor | Lee, Jinu | - |
dc.contributor.nonIdAuthor | Kim, Joo Hee | - |
dc.contributor.nonIdAuthor | Kim, Dong Goo | - |
dc.contributor.nonIdAuthor | Ahn, Young Soo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Heparin | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | ICAM-1 | - |
dc.subject.keywordAuthor | VCAM-1 | - |
dc.subject.keywordAuthor | Cerebral endothelial cells | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | LEUKOCYTE ADHESION | - |
dc.subject.keywordPlus | P-SELECTIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | CYTOKINES | - |
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