Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

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Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results Suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas. (c) 2006 Elsevier Inc. All rights reserved.
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2006-06
Language
English
Article Type
Article
Keywords

MOLECULAR REGULATION; METASTASIS; LYMPHANGIOGENESIS; ANGIOGENESIS; PROMOTES; VASCULATURE; GROWTH

Citation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.345, no.2, pp.545 - 551

ISSN
0006-291X
DOI
10.1016/j.bbrc.2006.04.121
URI
http://hdl.handle.net/10203/92825
Appears in Collection
BS-Journal Papers(저널논문)MSE-Journal Papers(저널논문)
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