Fabrication of CdSe/ZnS Quantum-Dot-Conjugated Protein Microarrays and Nanoarrays

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We demonstrate the fabrication and the detection of protein microarrays and nanoarrays, which are tagged by using colloidal CdSe/ZnS quantum dots (QDs), for the purpose of optical readout of those biochips. A microarrayer and a dip-pen nanolithography technique were used for the fabrication of QD-labeled protein microarrays and nanoarrays, respectively. The optical readout of those biochips was conducted by using a microchip scanner and a confocal scanning microscope in the case of the microarrays while an atomic force microscope was employed for characterizing the nanoarrays. We also report a possible way of reducing the 'doughnut phenomenon' in microarrays by varying the spot size from 300 mu m to 100 mu m, wherein the fluorescence intensity distribution becomes more uniform with decreasing spot diameter.
Publisher
KOREAN PHYSICAL SOC
Issue Date
2008-11
Language
English
Article Type
Article; Proceedings Paper
Keywords

ASSAY

Citation

JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.53, pp.3047 - 3050

ISSN
0374-4884
URI
http://hdl.handle.net/10203/91496
Appears in Collection
PH-Journal Papers(저널논문)
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