A new route to indolines by the Cu-catalyzed cyclization reaction of 2-ethynylanilines with sulfonyl azides

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It is revealed that 2-sulfonyliminoindolines can be efficiently synthesized by the Cu-catalyzed cyclization reaction of N-alkyl- or aryl-substituted 2-ethynylanilines with sulfonyl azides. This new route to the indoline derivatives is characterized by mild reaction conditions, facile introduction of functional groups at the 2-poiltion of the indoline ring, and the wide substrate scope. Selective transformation of indoline to oxindole and isatin analogs is also demonstrated.
Publisher
AMER CHEMICAL SOC
Issue Date
2008-03
Language
English
Article Type
Article
Keywords

ONE-POT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; COUPLING REACTIONS; AMIDE SYNTHESIS; INHIBITORS; DERIVATIVES; OXINDOLES; INDOLES; TMC-95A; 3-ALKYLIDENEOXINDOLES

Citation

ORGANIC LETTERS, v.10, no.6, pp.1163 - 1166

ISSN
1523-7060
DOI
10.1021/ol800049b
URI
http://hdl.handle.net/10203/91158
Appears in Collection
CH-Journal Papers(저널논문)
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