The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises

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dc.contributor.authorKim, JRko
dc.contributor.authorCho, Kwang-Hyunko
dc.date.accessioned2013-03-07T07:24:44Z-
dc.date.available2013-03-07T07:24:44Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2006-12-
dc.identifier.citationCOMPUTATIONAL BIOLOGY AND CHEMISTRY, v.30, pp.438 - 444-
dc.identifier.issn1476-9271-
dc.identifier.urihttp://hdl.handle.net/10203/89694-
dc.description.abstractE. coli has two-component systems composed of histidine kinase proteins and response regulator proteins. For a given extracellular stimulus, a histidine kinase senses the stimulus, autophosphorylates and then passes the phosphates to the cognate response regulators. The histidine kinase in an orthodox two-component system has only one histidine domain where the autophosphorylation occurs, but a histidine kinase in some unusual two-component systems (unorthodox two-component systems) has two histidine domains and one aspartate domain. So, the unorthodox two-component systems have more complex phosphorelay mechanisms than orthodox two-component systems. In general, the two-component systems are required to promptly respond to external stimuli for survival of E. coli. In this respect, the complex multi-step phosphorelay mechanism seems to be disadvantageous, but there are several unorthodox two-component systems in E. coli. In this paper, we investigate the reason why such unorthodox two-component systems are present in E. coli. For this purpose, we have developed simplified mathematical models of both orthodox and unorthodox two-component systems and analyzed their dynamical characteristics through extensive computer simulations. We have finally revealed that the unorthodox two-component systems realize ultrasensitive responses to external stimuli and also more robust responses to noises than the orthodox two-component systems. (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectSIGNAL-TRANSDUCTION SYSTEM-
dc.subjectTORR RESPONSE REGULATOR-
dc.subjectESCHERICHIA-COLI-
dc.subjectSENSOR-
dc.subjectPHOSPHORYLATION-
dc.subjectSENSITIVITY-
dc.subjectBVGAS-
dc.subjectEVGAS-
dc.subjectBARA-
dc.titleThe multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises-
dc.typeArticle-
dc.identifier.wosid000243091500006-
dc.identifier.scopusid2-s2.0-33751233848-
dc.type.rimsART-
dc.citation.volume30-
dc.citation.beginningpage438-
dc.citation.endingpage444-
dc.citation.publicationnameCOMPUTATIONAL BIOLOGY AND CHEMISTRY-
dc.identifier.doi10.1016/j.compbiolchem.2006.09.004-
dc.contributor.localauthorCho, Kwang-Hyun-
dc.contributor.nonIdAuthorKim, JR-
dc.type.journalArticleArticle-
dc.subject.keywordAuthortwo-component systems-
dc.subject.keywordAuthorunorthodox two-component systems-
dc.subject.keywordAuthorphosphorelay-
dc.subject.keywordAuthorultrasensitivity-
dc.subject.keywordAuthorrobustness-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION SYSTEM-
dc.subject.keywordPlusTORR RESPONSE REGULATOR-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusSENSOR-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusSENSITIVITY-
dc.subject.keywordPlusBVGAS-
dc.subject.keywordPlusEVGAS-
dc.subject.keywordPlusBARA-
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