GDF11 controls the timing of progenitor cell competence in developing retina

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The orderly generation of cell types in the developing retina is thought to be regulated by changes in the competence of multipotent progenitors. Here, we show that a secreted factor, growth and differentiation factor 11 (GDF11), controls the numbers of retinal ganglion cells (RGCs), as well as amacrine and photoreceptor cells, that form during development. GDF11 does not affect proliferation of progenitors-a major mode of GDF11 action in other tissues-but instead controls duration of expression of Maths, a gene that confers competence for RGC genesis, in progenitor cells. Thus, GDF11 governs the temporal windows during which multipotent progenitors retain competence to produce distinct neural progeny.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2005-06
Language
English
Article Type
Article
Keywords

GANGLION-CELLS; RAT RETINA; NEURAL RETINA; FROG RETINA; BHLH GENES; DIFFERENTIATION; MOUSE; AUTOREGULATION; RETINOGENESIS; EXPRESSION

Citation

SCIENCE, v.308, no.5730, pp.1927 - 1930

ISSN
0036-8075
DOI
10.1126/science.1110175
URI
http://hdl.handle.net/10203/88492
Appears in Collection
MSE-Journal Papers(저널논문)
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