Nanoparticle self-assembly gated by logical proteolytic triggers

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The emergent electromagnetic properties of nanoparticle self-assemblies are being harnessed to build new medical and biochemical assays with unprecedented sensitivity. While current self-assembly assays have displayed superior sensitivity for single molecular targets, the development of systems with the capacity to process multiple inputs may more effectively decipher complex disease signatures such as cancer. Herein, we present the design and synthesis of nanoparticles that perform Boolean logic operations using two proteolytic inputs associated with unique aspects of tumorigenesis (MMP2 and MMP7). Using dynamic light scatting, fluorescence, and MRI, we show that logical AND and OR functions can control the self-assembly of disperse superparamagnetic nanoparticles and enable remote, NMR detection of nanoparticle computation. In the future, by increasing the complexity of assembly triggers, nanoparticles may be tailored to sense a diversity of disease inputs in vitro and potentially in vivo.
Publisher
AMER CHEMICAL SOC
Issue Date
2007-05
Language
English
Article Type
Article
Keywords

MATRIX METALLOPROTEINASE-2; MAMMARY TUMORIGENESIS; GOLD NANOPARTICLES; BREAST-CARCINOMA; EXPRESSION; CLEAVAGE; INVASION; GELATIN; CANCER; TISSUE

Citation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.129, no.19, pp.6064 - 6064

ISSN
0002-7863
DOI
10.1021/ja070461l
URI
http://hdl.handle.net/10203/86147
Appears in Collection
BiS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
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