Functional insights gained from structural analyses of DNA duplexes that contain UV-damaged photoproducts

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Ultraviolet photolesions endow DNA with distinct structural and dynamic properties. Biophysical studies of photoproduct-containing DNA have shown that these lesions affect the mutagenic properties of DNA and damage recognition by DNA repair systems. Recently obtained high-resolution cocrystal structures of damaged DNA bound to either DNA polymerase or DNA repair enzymes have enriched our understanding of the mechanisms by which DNA lesions are bypassed or recognized by DNA metabolizing proteins. Here, we summarize the results of these structural studies and discuss their implications for DNA metabolism.
Publisher
AMER SOC PHOTOBIOLOGY
Issue Date
2007-01
Language
English
Article Type
Review
Keywords

NUCLEOTIDE EXCISION-REPAIR; CYCLOBUTANE PYRIMIDINE DIMER; SYN THYMINE DIMER; RELAXATION MATRIX REFINEMENT; CIS-SYN; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; DECAMER DUPLEX; SACCHAROMYCES-CEREVISIAE; SIMULATED SUNLIGHT

Citation

PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.83, no.1, pp.187 - 195

ISSN
0031-8655
DOI
10.1562/2006-02-28-IR-820
URI
http://hdl.handle.net/10203/86086
Appears in Collection
CH-Journal Papers(저널논문)
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