Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R-sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis

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We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. Box, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro. These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H2O2-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity.
Publisher
PHARMACEUTICAL SOC JAPAN
Issue Date
2002-08
Language
English
Article Type
Article
Keywords

PROLYL ENDOPEPTIDASE INHIBITORS; CENTRAL-NERVOUS-SYSTEM; UNDERGROUND PART; CELLS; ESTROGEN

Citation

BIOLOGICAL PHARMACEUTICAL BULLETIN, v.25, no.8, pp.1101 - 1104

ISSN
0918-6158
DOI
10.1248/bpb.25.1101
URI
http://hdl.handle.net/10203/85927
Appears in Collection
BS-Journal Papers(저널논문)
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