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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands

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dc.contributor.authorCha, MYko
dc.contributor.authorChoi, BCko
dc.contributor.authorKang, KHko
dc.contributor.authorPae, ANko
dc.contributor.authorChoi, KIko
dc.contributor.authorCho, YSko
dc.contributor.authorKoh, HYko
dc.contributor.authorLee, Hee Yoonko
dc.contributor.authorJung, Dko
dc.contributor.authorKong, JYko
dc.date.accessioned2013-03-04T18:01:53Z-
dc.date.available2013-03-04T18:01:53Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2002-05-
dc.identifier.citationBIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.12, no.10, pp.1327 - 1330-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10203/83550-
dc.description.abstractA piperazinylbutylisoxazole libary was designed, synthesized and screened for the binding affinities to dopamine D-2, D-3, and D-4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D-3 and D-4 receptors over the D-2 receptor. Compounds 6s and 6t showed K-i values of 2.6 nM and 3.9 nM for the D-3 receptor with 46- and 50-fold selectivity over the D-3 receptor, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectMOLECULAR-CLONING-
dc.subjectHIGH-AFFINITY-
dc.subjectD-3 RECEPTOR-
dc.subjectANTAGONIST-
dc.subjectGENE-
dc.subjectHALOPERIDOL-
dc.subjectEFFICACY-
dc.subjectAGONIST-
dc.subjectCYCLASE-
dc.subjectPOTENT-
dc.titleDesign and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands-
dc.typeArticle-
dc.identifier.wosid000175648800001-
dc.identifier.scopusid2-s2.0-18344391187-
dc.type.rimsART-
dc.citation.volume12-
dc.citation.issue10-
dc.citation.beginningpage1327-
dc.citation.endingpage1330-
dc.citation.publicationnameBIOORGANIC MEDICINAL CHEMISTRY LETTERS-
dc.contributor.localauthorLee, Hee Yoon-
dc.contributor.nonIdAuthorCha, MY-
dc.contributor.nonIdAuthorChoi, BC-
dc.contributor.nonIdAuthorKang, KH-
dc.contributor.nonIdAuthorPae, AN-
dc.contributor.nonIdAuthorChoi, KI-
dc.contributor.nonIdAuthorCho, YS-
dc.contributor.nonIdAuthorKoh, HY-
dc.contributor.nonIdAuthorJung, D-
dc.contributor.nonIdAuthorKong, JY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusMOLECULAR-CLONING-
dc.subject.keywordPlusHIGH-AFFINITY-
dc.subject.keywordPlusD-3 RECEPTOR-
dc.subject.keywordPlusANTAGONIST-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusHALOPERIDOL-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusAGONIST-
dc.subject.keywordPlusCYCLASE-
dc.subject.keywordPlusPOTENT-
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CH-Journal Papers(저널논문)
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