Discs-Large and Strabismus are functionally linked to plasma membrane formation

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During early embryogenesis in Drosophila melanogaster, extensive vesicle transport occurs to build cell boundaries for 6,000 nuclei. Here we show that this important process depends on a functional complex formed between the tumour suppressor and adaptor protein Discs-Large (Dlg)(1) and the integral membrane protein Strabismus (Stbm)/Van Gogh (Vang)(2,3). In support of this idea, embryos with mutations in either dlg or stbm displayed severe defects in plasma membrane formation. Conversely, overexpression of Dlg and Stbm synergistically induced excessive plasma membrane formation. In addition, ectopic co-expression of Stbm (which associated with post-Golgi vesicles) and the mammalian Dlg homologue SAP97/hDlg(4,5) promoted translocation of SAP97 from the cytoplasm to both post-Golgi vesicles and the plasma membrane. This effect was dependent on the interaction between Stbm and SAP97. These findings suggest that the Dlg-Stbm complex recruits membrane-associated proteins and lipids from internal membranes to sites of new plasma membrane formation.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2003-11
Language
English
Article Type
Letter
Keywords

TISSUE POLARITY; DROSOPHILA EYE; CELL POLARITY; GOLGI STACKS; PDZ PROTEINS; HOMOLOG; GENE; LOCALIZATION; DISRUPTION; JUNCTIONS

Citation

NATURE CELL BIOLOGY, v.5, no.11, pp.987 - 993

ISSN
1465-7392
DOI
10.1038/ncb1055
URI
http://hdl.handle.net/10203/81717
Appears in Collection
BS-Journal Papers(저널논문)
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