H-NS-dependent regulation of flagellar synthesis is mediated by a LysR family protein

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H-NS regulates the flagellar master operon (flhDC) and thus is necessary for flagellation of Escherichia coli. However, the molecular mechanism of its regulation has remained unknown. Genetic screening of a transposon insertion abolishing the H-NS effect revealed a previously unidentified gene, named hdfR, encoding a LysR family protein. Binding of purified HdfR to the flhDC promoter was demonstrated by a DNA mobility shift assay, indicating that HdfR is a transcriptional regulator for the flagellar master operon. Furthermore, the expression of the hdfR gene was shown to be negatively regulated by H-NS.
Publisher
AMER SOC MICROBIOLOGY
Issue Date
2000-08
Language
English
Article Type
Article
Keywords

DNA-BINDING PROTEIN; ESCHERICHIA-COLI; EXPRESSION; TRANSCRIPTION; VIRULENCE; FUSIONS; GENES; IDENTIFICATION; BACTERIOPHAGE; TYPHIMURIUM

Citation

JOURNAL OF BACTERIOLOGY, v.182, no.16, pp.4670 - 4672

ISSN
0021-9193
URI
http://hdl.handle.net/10203/77954
Appears in Collection
BS-Journal Papers(저널논문)
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