Design and synthesis of N-alkylated saccharins as selective alpha-1A adrenergic receptor antagonists

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Benign prostatic hyperplasia can be managed pharmacologically with alpha-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the alpha-1a receptor subtype may offer advantages in clinical applications with respect to hypotensive side effects. The N-alkylated saccharins reported here represent a new class of subtype selective alpha-1a adrenergic receptor antagonists which demonstrate potent effects on prostate function in vivo and are devoid of blood pressure side effects. (C) 1998 Elsevier Science Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
1998-09
Language
English
Article Type
Article; Proceedings Paper
Keywords

BENIGN PROSTATIC HYPERPLASIA; ALPHA(1C); EFFICACY; SAFETY

Citation

BIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.8, no.18, pp.2467 - 2472

ISSN
0960-894X
DOI
10.1016/S0960-894X(98)00446-6
URI
http://hdl.handle.net/10203/71556
Appears in Collection
CH-Journal Papers(저널논문)
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