Dephosphonylation of alpha-fully substituted beta-keto phosphonates with LiAlH4; Regioselective alkylation of ketones employing phosphonate as a temporary activating group
Alkylation of beta-keto phosphonates is performed by treatment of beta-keto phosphonates with n-BuLi, followed by addition of alkyl halides. The acquired a fully substituted beta-keto phosphonates are dephosphonylated by treatment of the lithium enolates with LiAlH4, followed by quenching with aqueous H2SO4 solution. This whole procedure represents a new route to regioselective alkylation of ketones. (C) 1997 Elsevier Science Ltd.
- Publisher
- Pergamon-Elsevier Science Ltd
- Issue Date
- 1997
- Language
- English
- Article Type
- Article
- Keywords
SULFONES
- Citation
TETRAHEDRON LETTERS, v.38, no.26, pp.4567 - 4570
- ISSN
- 0040-4039
- Appears in Collection
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