Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila

Cited 93 time in webofscience Cited 0 time in scopus
  • Hit : 305
  • Download : 0
The Drosophila eye disc is a sac of single layer epithelium with two opposing sides, the peripodial membrane (PM) and the disc proper (DP). Retinal morphogenesis is organized by Notch signaling at the dorsoventral (DV) boundary in the DP. Functions of the PM in coordinating growth and patterning of the DP are unknown. We show that the secreted proteins, Hedgehog, Wingless, and Decapentaplegic, are expressed in the PM, yet they control DP expression of Notch ligands, Delta and Serrate. Peripodial clones expressing Hedgehog induce Serrate in the DP while loss of peripodial Hedgehog disrupts disc growth. Furthermore, PM cells extend cellular processes to the DP. Therefore, peripodial signaling is critical for eye pattern formation and may be mediated by peripodial processes.
Publisher
CELL PRESS
Issue Date
2000-10
Language
English
Article Type
Article
Keywords

SEGMENT POLARITY GENE; RETINAL DIFFERENTIATION; MORPHOGENETIC FURROW; IMAGINAL DISKS; ADULT HEAD; WINGLESS; HEDGEHOG; MELANOGASTER; EXPRESSION; INDUCTION

Citation

CELL, v.103, no.2, pp.331 - 342

ISSN
0092-8674
DOI
10.1016/S0092-8674(00)00124-0
URI
http://hdl.handle.net/10203/68393
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 93 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0