DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Sang Chul | ko |
dc.contributor.author | Kang, Ho Kwon | ko |
dc.contributor.author | Park, Seung Ki | ko |
dc.contributor.author | Shin, Eun Ju | ko |
dc.date.accessioned | 2013-02-25T02:43:41Z | - |
dc.date.available | 2013-02-25T02:43:41Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1987 | - |
dc.identifier.citation | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v.37, no.1, pp.125 - 137 | - |
dc.identifier.issn | 1010-6030 | - |
dc.identifier.uri | http://hdl.handle.net/10203/59202 | - |
dc.description.abstract | Irradiation of human keratinocytes with UVB results in the early induction of proto-oncogenes c-fos and c-jun, members of the AP-1 protein family of transcription factors. To explore a possible involvement of oxidant stress in triggering this UVB-induced early gene response, we investigated in human keratinocytes the effect of N-acetylcysteine (NAG), a thiocompound with antioxidant activities, on UVB-induced c-fos, and c-jun expression. Normal human keratinocytes were irradiated with either 16 or 32 mi cm(-2) UVB, which induces a temporary inhibition of DNA synthesis, without compromising cell survival. Preincubation with 1 and 3 mM NAC suppressed c-jun and c-fos induction by UVB in a dose-dependent fashion. The applied concentrations of NAC were not toxic to the keratinocytes, as determined by Trypan Blue exclusion assay and completely suppressed c-jun and c-fos induction by the chemical cadmium chloride (oxidative stress). These results indicate that oxidative stress, at least in part, mediates the transcriptional activation of c-fos and c-jun in human keratinocytes after UVB irradiation. | - |
dc.language | English | - |
dc.publisher | Elsevier Science Sa | - |
dc.subject | CYCLOBUTANE PYRIMIDINE DIMERS | - |
dc.subject | SOLAR-SIMULATED IRRADIATION | - |
dc.subject | TYROSINE KINASES | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | HA-RAS | - |
dc.subject | ACTIVATION | - |
dc.subject | GENE | - |
dc.subject | PROTEIN | - |
dc.subject | SKIN | - |
dc.subject | INDUCTION | - |
dc.title | Photophysical Properties of the Some Coumarin Derivatives: 5,7-Dimethoxy-coumarin, 4',5'-Dihydropsoralen, 8-Methoxypsoralen, and 8-MOP<$_5$_'$_,$_6$_'$>THD C$_4$-Cyclomonadduct | - |
dc.type | Article | - |
dc.identifier.wosid | A1997WH17600017 | - |
dc.identifier.scopusid | 2-s2.0-0011422240 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 125 | - |
dc.citation.endingpage | 137 | - |
dc.citation.publicationname | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | - |
dc.identifier.doi | 10.1016/S1011-1344(96)07340-X | - |
dc.contributor.nonIdAuthor | Kang, Ho Kwon | - |
dc.contributor.nonIdAuthor | Park, Seung Ki | - |
dc.contributor.nonIdAuthor | Shin, Eun Ju | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | keratinocytes | - |
dc.subject.keywordAuthor | UVB | - |
dc.subject.keywordAuthor | N-acetylcysteine | - |
dc.subject.keywordAuthor | gene expression | - |
dc.subject.keywordPlus | CYCLOBUTANE PYRIMIDINE DIMERS | - |
dc.subject.keywordPlus | SOLAR-SIMULATED IRRADIATION | - |
dc.subject.keywordPlus | TYROSINE KINASES | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | HA-RAS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | INDUCTION | - |
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