DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kyu Seung Lee | ko |
dc.contributor.author | Tae Hee Han | ko |
dc.contributor.author | Ji Yoon Jo | ko |
dc.contributor.author | Gun Kang | ko |
dc.contributor.author | So Yeong Lee | ko |
dc.contributor.author | Pan Dong Ryu | ko |
dc.contributor.author | Jae Hyeng Im | ko |
dc.contributor.author | Byeong Hwa Jeon | ko |
dc.contributor.author | Jin Bong Park | ko |
dc.date.accessioned | 2008-07-11T08:46:06Z | - |
dc.date.available | 2008-07-11T08:46:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | NEUROSCIENCE LETTERS, v.439, no.2, pp.138 - 142 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/10203/5622 | - |
dc.description.abstract | Activation of serotonin (5-hydroxytryptamine, 5-HT) receptors produces various autonomic and neuroendocrine responses in the hypothalamic paraventricular nucleus (PVN), including increased blood pressure and heart rate. However, the role(s) of 5-HT on the local GABA synaptic circuit have not been well understood in the PVN, where the inhibitory neurotransmitter GABA plays a key role in the modulation of sympathoexcitatory outflow. In the present study, we examined the effects of 5-HT on GABA synaptic transmission in presympathetic PVN neurons projecting to spinal cord using patch-clamp electrophysiology combined with tract-tracing techniques. Bath application of 5-HT (0.01-100 mu M) reversibly decreased the frequency of spontaneous GABAergic inhibitory postsynaptic currents (sIPSC) in a concentration dependent manner (IC50, 0.07 mu M), with no significant changes in the amplitudes and decay kinetics of sIPSC. The sIPSC inhibition of 5-HT was mimicked by 5-HT1A agonist, 8-OH-DPAT (8-hydroxy-2(di-n-propylamino)tetralin, 10 mu M), and blocked by 5-HT1A antagonist WAY-100635 but not by 5-HT1B antagonist SB224289. 5-HT also reduced the frequency of miniature IPSC (mIPSC) (2.59 +/- 0.51 Hz, control vs. 1.25 +/- 0.31 Hz, 5-HT, n = 16) in similar extent with 5-HT induced reduction of sIPSC frequency (sIPSCs, 55.8 +/- 6.2%, n = 11 vs. mIPSCs, 52.30 +/- 5.85%, n = 16; p > 0.5). All together, our results indicate that 5-HT can inhibit presynaptic GABA release via presynaptic 5-HT1A receptors in presympathetic PVN neurons projecting to spinal cord. (C) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | RAT BASOLATERAL AMYGDALA | - |
dc.subject | RECEPTOR-MEDIATED INHIBITION | - |
dc.subject | SUPRACHIASMATIC NUCLEUS | - |
dc.subject | PRESYNAPTIC 5-HT1A | - |
dc.subject | SUPRAOPTIC NUCLEI | - |
dc.subject | HYPERTENSIVE-RATS | - |
dc.subject | CONSCIOUS RATS | - |
dc.subject | SPINAL-CORD | - |
dc.subject | HYPOTHALAMUS | - |
dc.subject | MODULATION | - |
dc.title | Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000257548500005 | - |
dc.identifier.scopusid | 2-s2.0-44649136016 | - |
dc.type.rims | ART | - |
dc.citation.volume | 439 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 138 | - |
dc.citation.endingpage | 142 | - |
dc.citation.publicationname | NEUROSCIENCE LETTERS | - |
dc.identifier.doi | 10.1016/j.neulet.2008.05.012 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jae Hyeng Im | - |
dc.contributor.nonIdAuthor | Kyu Seung Lee | - |
dc.contributor.nonIdAuthor | Tae Hee Han | - |
dc.contributor.nonIdAuthor | Ji Yoon Jo | - |
dc.contributor.nonIdAuthor | Gun Kang | - |
dc.contributor.nonIdAuthor | So Yeong Lee | - |
dc.contributor.nonIdAuthor | Pan Dong Ryu | - |
dc.contributor.nonIdAuthor | Byeong Hwa Jeon | - |
dc.contributor.nonIdAuthor | Jin Bong Park | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | 5-HT | - |
dc.subject.keywordAuthor | GABA | - |
dc.subject.keywordAuthor | sympathetic outflow | - |
dc.subject.keywordAuthor | paraventricular nucleus | - |
dc.subject.keywordAuthor | 5-HT1A receptor | - |
dc.subject.keywordPlus | RAT BASOLATERAL AMYGDALA | - |
dc.subject.keywordPlus | RECEPTOR-MEDIATED INHIBITION | - |
dc.subject.keywordPlus | SUPRACHIASMATIC NUCLEUS | - |
dc.subject.keywordPlus | PRESYNAPTIC 5-HT1A | - |
dc.subject.keywordPlus | SUPRAOPTIC NUCLEI | - |
dc.subject.keywordPlus | HYPERTENSIVE-RATS | - |
dc.subject.keywordPlus | CONSCIOUS RATS | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | HYPOTHALAMUS | - |
dc.subject.keywordPlus | MODULATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.