We propose an integrated supply chain management framework that allows us to explicitly consider the impact of product perishability on a broad scale that includes manufacturers, distribution centers, wholesalers, and demand markets. The framework proposed herein also makes it possible to consider the oligopolistic competition across wholesalers that drives price and demand fluctuations. Furthermore, the supply chain decision rules are derived from necessary conditions in the framework. The inclusion of such salient features allows the framework to generate outcomes that suggest realistic managerial in-sights. We provide a numerical example in which two multi-national pharmaceutical firms producing a homogeneous medicinal drug and four oligopolistic wholesalers are considered.