HIV-1 tat protein inactivates notch signaling = HIV-1 Tat 단백질에 의한 Notch 신호전달의 억제

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In addition to the stimulation of HIV-1 transcription, Tat protein, which is secreted by the infected cells, exerts pleiotropic effects on uninfected bystander cells. This seems to be mediated by the interaction between Tat protein and extracellular Notch receptor. Co-immunoprecipitation and GST pull-down assay have revealed the interaction between HIV-1 Tat and hN2E1~6 (human Notch2 EGF-like repeats 1~6). Treatment of Tat protein interfered with Notch signaling in Jurkat cells in which the expression of Notch receptor and ligand are abundant. Dose dependent transcriptional repression of Notch responsive HES-1 gene was observed in Tat treated Jurkat cells.
Advisors
Cho, Cheol-Oresearcher조철오researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2007
Identifier
268826/325007  / 020053972
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2007. 8, [ v, 41 p. ]

Keywords

HIV-1 Tat protein; Notch signaling; HIV-1 Tat 단백질; Notch 신호전달; HIV-1 Tat protein; Notch signaling; HIV-1 Tat 단백질; Notch 신호전달

URI
http://hdl.handle.net/10203/28095
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=268826&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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