(An) integrative analysis tool to identify genome-wide cis-regulatory modules : combinatorial CRM decoder (CCD) = Genome-wide cis-regulatory modules을 찾는 통합적인 분석 프로그램 : Combinatorial CRM decoder (CCD) combinatorial CRM decoder (CCD)

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Integrative analysis of a large amount of information accumulated in public databases can provide new biological insights, although the lack of robust methodologies has become a major bottleneck. Here, I present a comprehensive analysis tool called combinatorial CRM decoder (CCD), which utilizes publicly available information to identify and characterize genome-wide cis-regulatory modules (CRMs). Using 61 genome-wide datasets, CCD successfully pinpointed more than 8,000 CRMs in the mouse genome. Further investigations identified 2,519 polycomb repressive complex 2 (PRC2) target sites as well as a signature of the imprinting control regions (ICRs) in mouse embryonic stem (ES) cells. Moreover, CCD discovered a new type of CRM named ‘multi-functional CRM’, which is presumed to be capable of switching functions by the binding of different combinations of transcription factors. Overall, these results demonstrate the remarkable capability of CCD in the field of integrative analysis.
Advisors
Lee, Dae-Youpresearcher이대엽researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2011
Identifier
466358/325007  / 020068501
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2011.2, [ vi, 167 p. ]

Keywords

Polycomb repressive complex 2; Genome-wide ChIP-seq; cis-regulatory modules; Integrative analysis; Imprinting control regions; 유전자각인 조절모듈; 폴리콤 컴플렉스 2; 전체 유전체; 조절모듈; 통합분석

URI
http://hdl.handle.net/10203/27714
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=466358&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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