Synthetic Strategies for (-)-Cannabidiol and Its Structural Analogs

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(-)-Cannabidiol ((-)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (-)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (-)-CBD could tackle these issues, and, additionally, generate novel (-)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (-)-CBD and its analogs.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2019-11
Language
English
Article Type
Review
Citation

CHEMISTRY-AN ASIAN JOURNAL, v.14, no.21, pp.3749 - 3762

ISSN
1861-4728
DOI
10.1002/asia.201901179
URI
http://hdl.handle.net/10203/268844
Appears in Collection
CH-Journal Papers(저널논문)
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